Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTM9XSU)

DTT Name	Candida Squalene epoxidase (Candi ERG1)
Synonyms	Candi Squalene monooxygenase; Candi Squalene epoxidase; Candi SE
Gene Name	Candi ERG1
DTT Type	Successful target	[1]
UniProt ID	ERG1_CANAL
TTD ID	T78173
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSSVKYDAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALREL GMIKAINNIRAVDCTGYYIKYYDETITIPYPLKKDACITNPVKPVPDAVDGVNDKLDSDS TLNVDDWDFDERVRGAAFHHGDFLMNLRQICRDEPNVTAVEATVTKILRDPSDPNTVIGV QTKQPSGTVDYHAKLTISCDGIYSKFRKELSPTNVPTIGSYFIGLYLKNAELPAKGKGHV LLGGHAPALIYSVSPTETRVLCVYVSSKPPSAANDAVYKYLRDNILPAIPKETVPAFKEA LEERKFRIMPNQYLSAMKQGSENHKGFILLGDSLNMRHPLTGGGMTVGLNDSVLLAKLLH PKFVEDFDDHQLIAKRLKTFHRKRKNLDAVINTLSISLYSLFAADKKPLRILRNGCFKYF QRGGECVNGPIGLLSGMLPFPMLLFNHFFSVAFYSVYLNFIERGLLGFPLALFEAFEVLF TAIVIFTPYLWNEIVR
Function	Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
KEGG Pathway	Steroid biosynthesis (cal00100 ) Sesquiterpenoid and triterpenoid biosynthesis (cal00909 ) Metabolic pathways (cal01100 ) Biosynthesis of secondary metabolites (cal01110 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Butenafine	DMOJ4ZI	Dermatologic infection	1F28	Approved	[1]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[1]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.