Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMPZ7V)

DTT Name Interleukin 13 receptor alpha-2 (IL13RA2)
Synonyms
Interleukin-13-binding protein; Interleukin-13 receptor subunit alpha-2; Interleukin-13 binding protein; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; IL-13R alpha-2 chain; IL-13 receptor subunit alpha-2; CD213a2
Gene Name IL13RA2
DTT Type
Clinical trial target
 [1]
BioChemical Class
Cytokine receptor
UniProt ID
I13R2_HUMAN
TTD ID
T40459
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD
HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ
SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH
ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP
PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE
TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG
LLLRKPNTYPKMIPEFFCDT
Function Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
KEGG Pathway
Jak-STAT signaling pathway (hsa04630 )
Reactome Pathway
Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tralokinumab DM6ENSJ Atopic dermatitis EA80 Approved [2]
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3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ICT-107 DMBIZ7H Brain cancer 2A00 Phase 3 [1]
ABT-308 DM6WN2D Eosinophilic esophagitis DA24.1 Phase 2 [3]
MB-101 DMLA1QD Recurrent glioblastoma 2A00.00 Phase 1 [4]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Glioma 2C82 Brainstem tissue 4.40E-01 2.46 1
Glioma 2C82 White matter 5.77E-05 4.14 2.11
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References

1 Clinical pipeline report, company report or official report of ImmunoCellular Therapeutics.
2 Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model.Am J Respir Cell Mol Biol.2014 May;50(5):985-94.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)