Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMTF2P)

DTT Name Citrate hydro-lyase (ACO2)
Synonyms Aconitase; ACO2
Gene Name ACO2
DTT Type
Literature-reported target
 [1]
BioChemical Class
Alpha-carbonic anhydrase
UniProt ID
ACON_HUMAN
TTD ID
T12627
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 4.2.1.3
Sequence
MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
RPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAV
PSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILEN
YAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSG
WSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYN
HRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHP
VAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGS
EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRN
DANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPG
QDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAA
GPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVI
GDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP
VDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
Function Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
KEGG Pathway
Citrate cycle (TCA cycle) (hsa00020 )
Glyoxylate and dicarboxylate metabolism (hsa00630 )
Metabolic pathways (hsa01100 )
Biosynthesis of antibiotics (hsa01130 )
Carbon metabolism (hsa01200 )
2-Oxocarboxylic acid metabolism (hsa01210 )
Biosynthesis of amino acids (hsa01230 )
Reactome Pathway
Mitochondrial protein import (R-HSA-1268020 )
BioCyc Pathway
MetaCyc:HS02077-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
5 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
4-Hydroxy-Aconitate Ion DMT8L5R Discovery agent N.A. Investigative [1]
Aconitate Ion DMJ5U8C Discovery agent N.A. Investigative [1]
Alpha-Methylisocitric Acid DM3YGWL Discovery agent N.A. Investigative [1]
Isocitric Acid DMJKW4S Discovery agent N.A. Investigative [1]
Tricarballylic Acid DMLKWTG Discovery agent N.A. Investigative [1]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.