Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTNC3WS)

DTT Name	Apolipoprotein A-IV (APOA4)
Synonyms	Apolipoprotein A4; ApoAIV; APOA4
Gene Name	APOA4
DTT Type	Literature-reported target	[1]
BioChemical Class	Apolipoprotein
UniProt ID	APOA4_HUMAN
TTD ID	T68829
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV SQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLR PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
Function	May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
KEGG Pathway	Fat digestion and absorption (hsa04975 ) Vitamin digestion and absorption (hsa04977 ) Cholesterol metabolism (hsa04979 ) Lipid and atherosclerosis (hsa05417 )
Reactome Pathway	Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889 ) Chylomicron remodeling (R-HSA-8963901 ) Retinoid metabolism and transport (R-HSA-975634 ) Amyloid fiber formation (R-HSA-977225 ) Chylomicron assembly (R-HSA-8963888 )

References

1	Apolipoprotein L1 and apolipoprotein A-IV and their association with kidney function. Curr Opin Lipidol. 2017 Feb;28(1):39-45.