Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTNLDK6)

DTT Name	Cardiac troponin I (TNNI3)
Synonyms	TNNI3
Gene Name	TNNI3
DTT Type	Literature-reported target	[1]
BioChemical Class	Troponin
UniProt ID	TNNI3_HUMAN
TTD ID	T20186
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQE LEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTK NITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKED TEKENREVGDWRKNIDALSGMEGRKKKFES
Function	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
KEGG Pathway	cAMP signaling pathway (hsa04024 ) Cardiac muscle contraction (hsa04260 ) Adrenergic signaling in cardiomyocytes (hsa04261 ) Hypertrophic cardiomyopathy (hsa05410 ) Dilated cardiomyopathy (hsa05414 ) Diabetic cardiomyopathy (hsa05415 )
Reactome Pathway	Ion homeostasis (R-HSA-5578775 ) Striated Muscle Contraction (R-HSA-390522 )

References

1	Circulating, imaging, and genetic biomarkers in cardiovascular risk prediction. Trends Cardiovasc Med. 2011 May;21(4):105-12.