Details of the Drug Therapeutic Target (DTT) | DrugMAP

General Information of Drug Therapeutic Target (DTT) (ID: TTNLFBE)

DTT Name	Glutathione S-transferase A2 (GSTA2)
Synonyms	GTH2; GSTA2-2; GST2; GST-gamma; GST class-alpha member 2; GST HA subunit 2
Gene Name	GSTA2
DTT Type	Literature-reported target				[1]
UniProt ID	GSTA2_HUMAN
TTD ID	T53510
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.5.1.18
Sequence	MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
KEGG Pathway	Glutathione metabolism (hsa00480 ) Metabolism of xenobiotics by cytochrome P450 (hsa00980 ) Drug metabolism - cytochrome P450 (hsa00982 ) Drug metabolism - other enzymes (hsa00983 ) Metabolic pathways (hsa01100 ) Platinum drug resistance (hsa01524 ) Pathways in cancer (hsa05200 ) Chemical carcinogenesis - DNA adducts (hsa05204 ) Chemical carcinogenesis - receptor activation (hsa05207 ) Chemical carcinogenesis - reactive oxygen species (hsa05208 ) Hepatocellular carcinoma (hsa05225 ) Fluid shear stress and atherosclerosis (hsa05418 )
Reactome Pathway	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (R-HSA-8950505 ) Azathioprine ADME (R-HSA-9748787 ) Glutathione conjugation (R-HSA-156590 )
BioCyc Pathway	MetaCyc:HS01846-MON

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Glutathione S-transferase alpha-2 (GSTA2) DME Info

Gene Name

GSTA2

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[2]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[3]
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References

1	Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form. Pharmacogenetics. 2004 Jan;14(1):35-44.
2	PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
3	Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302.