Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTNS6X4)

• DTT Name: Bacterial Triosephosphate isomerase (Bact TPI)
• Synonyms: Triose-phosphate isomerase; TPI; TIM
• Gene Name: Bact TPI
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Intramolecular oxidoreductase
• UniProt ID: TPIS_PLAFA
• TTD ID: T59130
• EC Number: EC 5.3.1.1
• Sequence:
  MARKYFVAANWKCNGTLESIKSLTNSFNNLDFDPSKLDVVVFPVSVHYDHTRKLLQSKFS
  TGIQNVSKFGNGSYTGEVSAEIAKDLNIEYVIIGHFERRKYFHETDEDVREKLQASLKNN
  LKAVVCFGESLEQREQNKTIEVITKQVKAFVDLIDNFDNVILAYEPLWAIGTGKTATPEQ
  AQLVHKEIRKIVKDTCGEKQANQIRILYGGSVNTENCSSLIQQEDIDGFLVGNASLKESF
  VDIIKSAM
• Function: identical protein binding, triose-phosphate isomerase activity.

Molecular Interaction Atlas (MIA) of This DTT

6 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Phosphoglyceric Acid	DMX6GH5	Discovery agent	N.A.	Investigative	[1]
2-Phosphoglycolic Acid	DMO14NH	Discovery agent	N.A.	Investigative	[1]
3-Hydroxypyruvic Acid	DM67QDT	Discovery agent	N.A.	Investigative	[1]
3-Phosphoglyceric Acid	DMIK9VO	Discovery agent	N.A.	Investigative	[1]
3-Phosphoglycerol	DM9BDV2	Discovery agent	N.A.	Investigative	[1]
Glycerol-2-Phosphate	DM0J5KF	Discovery agent	N.A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.