Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTNZKFJ)

DTT Name	Fanconi anemia group F protein (FANCF)
Synonyms	Protein FACF
Gene Name	FANCF
DTT Type	Literature-reported target	[1]
UniProt ID	FANCF_HUMAN
TTD ID	T75419
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MESLLQHLDRFSELLAVSSTTYVSTWDPATVRRALQWARYLRHIHRRFGRHGPIRTALER RLHNQWRQEGGFGRGPVPGLANFQALGHCDVLLSLRLLENRALGDAARYHLVQQLFPGPG VRDADEETLQESLARLARRRSAVHMLRFNGYRENPNLQEDSLMKTQAELLLERLQEVGKA EAERPARFLSSLWERLPQNNFLKVIAVALLQPPLSRRPQEELEPGIHKSPGEGSQVLVHW LLGNSEVFAAFCRALPAGLLTLVTSRHPALSPVYLGLLTDWGQRLHYDLQKGIWVGTESQ DVPWEELHNRFQSLCQAPPPLKDKVLTALETCKAQDGDFEVPGLSIWTDLLLALRSGAFR KRQVLGLSAGLSSV
Function	May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function.
KEGG Pathway	Fanconi anemia pathway (hsa03460 )
Reactome Pathway	Fanconi Anemia Pathway (R-HSA-6783310 )

References

1	Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene. 2004 Jan 29;23(4):1000-4.