Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTO8YH2)

DTT Name	Plasmodium Serine hydroxymethyltransferase (Malaria SHMT)
Synonyms	Serine methylase; SHMT; Glycine hydroxymethyltransferase
Gene Name	Malaria SHMT
DTT Type	Literature-reported target	[1]
BioChemical Class	Methyltransferase
UniProt ID	Q8I566_PLAF7
TTD ID	T55826
EC Number	EC 2.1.2.1
Sequence	MFNNDPLQKYDKELFDLLEKEKNRQIETINLIASENLTNTAVRECLGDRISNKYSEGYPH KRYYGGNDYVDKIEELCYKRALEAFNVSEEEWGVNVQPLSGSAANVQALYALVGVKGKIM GMHLCSGGHLTHGFFDEKKKVSITSDLFESKLYKCNSEGYVDMESVRNLALSFQPKVIIC GYTSYPRDIDYKGFREICDEVNAYLFADISHISSFVACNLLNNPFTYADVVTTTTHKILR GPRSALIFFNKKRNPGIDQKINSSVFPSFQGGPHNNKIAAVACQLKEVNTPFFKEYTKQV LLNSKALAECLLKRNLDLVTNGTDNHLIVVDLRKYNITGSKLQETCNAINIALNKNTIPS DVDCVSPSGIRIGTPALTTRGCKEKDMEFIADMLLKAILLTDELQQKYGKKLVDFKKGLV NNPKIDELKKEVVQWAKNLPFA
Function	Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.
KEGG Pathway	Glycine, serine and threonine metabolism (hsa00260 ) Cyanoamino acid metabolism (hsa00460 ) Glyoxylate and dicarboxylate metabolism (hsa00630 ) One carbon pool by folate (hsa00670 ) Metabolic pathways (hsa01100 ) Biosynthesis of antibiotics (hsa01130 ) Carbon metabolism (hsa01200 ) Biosynthesis of amino acids (hsa01230 )
Reactome Pathway	Metabolism of folate and pterines (R-HSA-196757 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mimosine	DMQB8TW	N. A.	N. A.	Terminated	[1]
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References

1	Mimosine targets serine hydroxymethyltransferase. J Biol Chem. 1996 Feb 2;271(5):2548-56.