Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOJ46K)

DTT Name Streptococcus Methionyl-tRNA synthetase (Stre-coc metG)
Synonyms
metG; Methionyl-transferribonucleic acid synthetase; Methionyl-transferribonucleate synthetase; Methionyl-transferRNA synthetase; Methionyl t-RNA synthetase; Methionine-tRNA ligase; Methionine--tRNA ligase; Methionine translase; MetRS; MRS
Gene Name Stre-coc metG
DTT Type
Clinical trial target
 [1]
BioChemical Class
Carbon-oxygen ligase
UniProt ID
SYM_STRP1
TTD ID
T27198
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 6.1.1.10
Sequence
MKKPFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRLMGHEVFYLTGLDEHGQKIQTKA
KEAGITPQTYVDNMAKDVKALWQLLDISYDTFIRTTDDYHEEVVAAVFEKLLAQDDIYLG
EYSGWYSVSDEEFFTESQLKEVFRDEDGQVIGGIAPSGHEVEWVSEESYFLRLSKYDDRL
VAFFKERPDFIQPDGRMNEMVKNFIEPGLEDLAVSRTTFTWGVPVPSDPKHVVYVWIDAL
LNYATALGYRQANHANFDKFWNGTVFHMVGKDILRFHSIYWPILLMMLDLPMPDRLIAHG
WFVMKDGKMSKSKGNVVYPEMLVERFGLDPLRYYLMRSLPVGSDGTFTPEDYVGRINYEL
ANDLGNLLNRTVAMINKYFDGTVPAYVDNGTAFDADLSQLIDAQLADYHKHMEAVDYPRA
LEAVWTIIARTNKYIDETAPWVLAKEDGDKAQLASVMAHLAASLRLVAHVIQPFMMETSA
AIMAQLGLEPVSDLSTLALADFPANTKVVAKGTPIFPRLDMEAEIDYIKAQMGDSSAISQ
EKEWVPEEVALKSEKDVITFETFDAVEIRVAEVKEVSKVEGSEKLLRFRVDAGDGQDRQI
LSGIAKFYPNEQELVGKKLQIVANLKPRKMMKKYISQGMILSAEHGDQLTVLTVDSSVPN
GSIIG
Function Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
KEGG Pathway
Selenocompound metabolism (spy00450 )
Aminoacyl-tRNA biosynthesis (spy00970 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
REP8839 DMZJH23 Bacterial infection 1A00-1C4Z Phase 1 [1]
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3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
5'-O-[(L-Methionyl)-Sulphamoyl]Adenosine DM20X8C Discovery agent N.A. Investigative [2]
Difluoromethionine DM8TG41 Discovery agent N.A. Investigative [2]
Methionine Phosphonate DMOUTNA Discovery agent N.A. Investigative [2]
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References

1 Antibacterial activity of REP8839, a new antibiotic for topical use. Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.