Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOMVUW)

DTT Name	Pseudomonas Transcriptional activator protein LasR (Pseudo LasR)
Gene Name	Pseudo LasR
DTT Type	Preclinical target	[1]
UniProt ID	LASR_PSEAE
TTD ID	T20534
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAW REHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHG ARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSR EKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
Function	Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
KEGG Pathway	Quorum sensing (pae02024 ) Biofilm formation - Pseudomonas aeruginosa (pae02025 )
BioCyc Pathway	PAER208964:G1FZ6-1456-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-Oxo-C12-(2-amino-cyclohexanone)	DM5CVBM	Pseudomonas infection	1B92	Preclinical	[1]
C30	DMY9F1M	Pseudomonas infection	1B92	Preclinical	[1]
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References

1	Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471.