Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTOYT5L)

DTT Name	Dipeptidyl-peptidase 7 (DPP7)
Synonyms	Quiescent cell proline dipeptidase; QPP; Dipeptidyl peptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase 2; Dipeptidyl aminopeptidase II; DPP2; DPP II
Gene Name	DPP7
DTT Type	Patented-recorded target	[1]
UniProt ID	DPP2_HUMAN
TTD ID	T50773
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.4.14.2
Sequence	MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ QPALRGGPRLSL
Function	Plays an important role in the degradation of some oligopeptides.
Reactome Pathway	Neutrophil degranulation (R-HSA-6798695 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

8 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BDBM50382283	DMQJ5S8	N. A.	N. A.	Patented	[2]
BDBM50434164	DM6DFTX	N. A.	N. A.	Patented	[2]
BDBM50434165	DMDTYJ9	N. A.	N. A.	Patented	[2]
CRWCYVOHVXAEMF-LBPRGKRZSA-N	DMBV5Z0	N. A.	N. A.	Patented	[2]
US8470836, 2	DMH7JVA	N. A.	N. A.	Patented	[3]
US8470836, 5	DMYR10P	N. A.	N. A.	Patented	[3]
US8470836, 6	DMVYQXH	N. A.	N. A.	Patented	[3]
US8470836, 8	DMM4GLH	N. A.	N. A.	Patented	[3]
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⏷ Show the Full List of 8 Patented Agent(s)

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N4-(4-chlorobenzyl)-2,4-diaminobutanoylpiperidine	DMARZHU	Discovery agent	N.A.	Investigative	[1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Dipeptidyl peptidase II (DPP7) DME Info

Gene Name

DPP7

1 Clinical Trial Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BRADYKININ	DM4R6UV	N. A.	N. A.	Phase 1	[4]
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References

1	Dipeptidyl peptidase II and leukocyte cell death. Biochem Pharmacol. 2006 Jun 28;72(1):70-9.
2	FAP inhibitors. US9346814.
3	Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent. US8470836.
4	Purification of two dipeptidyl aminopeptidases II from rat brain and their action on proline-containing neuropeptides. J Neurochem. 1989 Apr;52(4):1284-93.