Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTP1UKZ)

DTT Name Thymidylate synthase messenger RNA (TYMS mRNA)
Synonyms TSase (mRNA); TS (mRNA); OK/SW-cl.29 (mRNA)
Gene Name TYMS
DTT Type
Successful target
 [1]
BioChemical Class
mRNA target
UniProt ID
TYSY_HUMAN
TTD ID
T79249
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.1.1.45
Sequence
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
Function Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
KEGG Pathway
Pyrimidine metabolism (hsa00240 )
One carbon pool by folate (hsa00670 )
Metabolic pathways (hsa01100 )
Nucleotide metabolism (hsa01232 )
Antifolate resistance (hsa01523 )
Reactome Pathway
G1/S-Specific Transcription (R-HSA-69205 )
Interconversion of nucleotide di- and triphosphates (R-HSA-499943 )
BioCyc Pathway
MetaCyc:HS11096-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Thymidylate synthase (TYMS) DME Info
Gene Name TYMS
2 Approved Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [2]
Methotrexate DM2TEOL Anterior urethra cancer Approved [3]
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1 Investigative Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2'-deoxyuridylic acid DMPV1LU Discovery agent N.A. Investigative [4]
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References

1 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
2 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65.
3 The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
4 Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem. 2002 Sep 27;277(39):36304-11.