Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTP8UCK)

DTT Name Bacterial Glycosyltransferase MurG (Bact murG)
Synonyms Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; MurG
Gene Name Bact murG
DTT Type
Literature-reported target
 [1]
BioChemical Class
Hexosyltransferase
UniProt ID
MURG_ECOLI
TTD ID
T07466
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.4.1.227
Sequence
MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFI
RISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIP
VVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGRE
GPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKV
TEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGA
AKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRVARA
Function
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II).
KEGG Pathway
Peptidoglycan biosynthesis (ecj00550 )
Metabolic pathways (ecj01100 )
Vancomycin resistance (ecj01502 )
BioCyc Pathway
MetaCyc:NACGLCTRANS-MON
EcoCyc:NACGLCTRANS-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Uridine-Diphosphate-N-Acetylgalactosamine DMXHO6J N. A. N. A. Investigative [1]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.