Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTPS7KA)

• DTT Name: Bacterial Dehydroquinate synthase (Bact aroB)
• Synonyms: DHQS; 3-dehydroquinate synthase
• Gene Name: Bact aroB
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Alpha-carbonic anhydrase
• UniProt ID: AROB_ECOLI
• TTD ID: T86717
• Sequence:
  MERIVVTLGERSYPITIASGLFNEPASFLPLKSGEQVMLVTNETLAPLYLDKVRGVLEQA
  GVNVDSVILPDGEQYKSLAVLDTVFTALLQKPHGRDTTLVALGGGVVGDLTGFAAASYQR
  GVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPASVVVDLDCLKTLPPRELAS
  GLAEVIKYGIILDGAFFNWLEENLDALLRLDGPAMAYCIRRCCELKAEVVAADERETGLR
  ALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGMVMAARTSERLGQFSSAETQRIITLLKRA
  GLPVNGPREMSAQAYLPHMLRDKKVLAGEMRLILPLAIGKSEVRSGVSHELVLNAIADCQ
  SA
• Function: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
• KEGG Pathway:
  Phenylalanine, tyrosine and tryptophan biosynthesis (ecj00400)
  Metabolic pathways (ecj01100)
  Biosynthesis of secondary metabolites (ecj01110)
  Biosynthesis of amino acids (ecj01230)
• BioCyc Pathway:
  MetaCyc:AROB-MON
  EcoCyc:AROB-MON

Molecular Interaction Atlas (MIA) of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbaphosphonate	DMGFLI7	Discovery agent	N.A.	Investigative	[1]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.