Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTPSK7A)

• DTT Name: Plexin domain-containing protein 1 (PLXDC1)
• Synonyms: Tumor endothelial marker 7; Tumor endothelial marker 3; PLXDC1
• Gene Name: PLXDC1
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Plexin family
• UniProt ID: PLDX1_HUMAN
• TTD ID: T63580
• Sequence:
  MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDR
  TQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVK
  IHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMA
  NFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPM
  SVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTP
  LPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQ
  DEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGT
  PVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHST
  YAEVEPSGHEKEGFMEAEQC
• Function: Plays a critical role in endothelial cell capillarymorphogenesis.

References

• [1] Glioblastoma endothelium drives bevacizumab-induced infiltrative growth via modulation of PLXDC1. Int J Cancer. 2019 Mar 15;144(6):1331-1344.