Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQALFH)

• DTT Name: Bacterial Beta-glucuronidase (Bact uidA)
• Synonyms: GUS; Beta-D-glucuronoside glucuronosohydrolase
• Gene Name: Bact uidA
• DTT Type: Preclinical target; [1]
• UniProt ID: BGLR_ECOLI
• TTD ID: T14705
• EC Number: EC 3.2.1.31
• Sequence:
  MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI
  RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP
  YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP
  NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH
  LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD
  LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS
  LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG
  AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET
  AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV
  SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG
  GKQ
• Function: cytosol, protein-containing complex, beta-glucuronidase activity, carbohydrate binding, identical protein binding, glucuronoside catabolic process
• KEGG Pathway:
  Pentose and glucuronate interconversions (ecj00040)
  Ascorbate and aldarate metabolism (ecj00053)
  Porphyrin metabolism (ecj00860)
  Metabolic pathways (ecj01100)
  Biosynthesis of secondary metabolites (ecj01110)
  Biosynthesis of cofactors (ecj01240)
• BioCyc Pathway:
  MetaCyc:BETA-GLUCURONID-MON
  EcoCyc:BETA-GLUCURONID-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SBX-101	DMXN4UC	Intestinal toxicities from therapy	DA94.1	Preclinical	[1]

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Beta-glucuronidase (uidA) DME Info
• Gene Name: uidA

1 Investigative Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin glucuronide	DMSBENK	N. A.	N. A.	Investigative	[2]

References

• [1] Microbiome therapeutics go small molecule. Nat Rev Drug Discov. 2019 Jul;18(8):569-572.
• [2] Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.