Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQWGU9)

DTT Name	Bacterial Aspartate-semialdehyde dehydrogenase (Bact asd2)
Synonyms	asd2; L-Aspartate-beta-semialdehyde dehydrogenase; ASADH; ASA dehydrogenase
Gene Name	Bact asd2
DTT Type	Literature-reported target	[1]
BioChemical Class	Aldehyde/oxo donor oxidoreductase
UniProt ID	DHAS2_VIBCH
TTD ID	T59729
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSQQFNVAIFGATGAVGETMLEVLQEREFPVDELFLLASERSEGKTYRFNGKTVRVQNVE EFDWSQVHIALFSAGGELSAKWAPIAAEAGVVVIDNTSHFRYDYDIPLVVPEVNPEAIAE FRNRNIIANPNCSTIQMLVALKPIYDAVGIERINVTTYQSVSGAGKAGIDELAGQTAKLL NGYPAETNTFSQQIAFNCIPQIDQFMDNGYTKEEMKMVWETQKIFNDPSIMVNPTCVRVP VFYGHAEAVHVETRAPIDAEQVMDMLEQTDGIELFRGADFPTQVRDAGGKDHVLVGRVRN DISHHSGINLWVVADNVRKGAATNAVQIAELLVRDYF
Function	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate.
KEGG Pathway	Glycine, serine and threonine metabolism (vch00260 ) Monobactam biosynthesis (vch00261 ) Cysteine and methionine metabolism (vch00270 ) Lysine biosynthesis (vch00300 ) Metabolic pathways (vch01100 ) Biosynthesis of secondary metabolites (vch01110 ) Microbial metabolism in diverse environments (vch01120 ) 2-Oxocarboxylic acid metabolism (vch01210 ) Biosynthesis of amino acids (vch01230 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

4 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[1]
Aspartate Semialdehyde	DMGB90V	Discovery agent	N.A.	Investigative	[1]
Cacodylate Ion	DMK4XLD	Discovery agent	N.A.	Investigative	[1]
S-sulpho-L-cysteine	DMDIYWV	Discovery agent	N.A.	Investigative	[2]
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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp. J Nat Prod. 2005 May;68(5):804-6.