Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQYVKD)

• DTT Name: Fru-2,6-P2ase 2/6PF-2-K (PFK/FBPase 2)
• Synonyms: PFKFB2; PFK-2/FBPase-2; 6PF-2-K/Fru-2,6-P2ASE heart-typeisozyme
• Gene Name: PFKFB2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Kinase
• UniProt ID: F262_HUMAN
• TTD ID: T20776
• Sequence:
  MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTR
  YLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEE
  NGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPE
  RNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVY
  YLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVW
  TSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY
  PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTI
  FKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPR
  NYSVGSRPLKPLSPLRAQDMQEGAD
• Function: Synthesis and degradation of fructose 2,6-bisphosphate.
• KEGG Pathway:
  Fructose and mannose metabolism (hsa00051)
  Metabolic pathways (hsa01100)
  AMPK signaling pathway (hsa04152)
  Thyroid hormone signaling pathway (hsa04919)
• Reactome Pathway: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (R-HSA-9634600)
• BioCyc Pathway: MetaCyc:HS04690-MON

References

• [1] Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress. FEBS Lett. 2000 Sep 1;480(2-3):261-4.