Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTR01E9)

DTT Name	Mannan-binding lectin serine protease-2 (MASP2)
Synonyms	Mannosebinding proteinassociated serine protease 2; Mannanbinding lectin serine protease 2 B chain; Mannanbinding lectin serine protease 2; MBLassociated serine protease 2; MASP2
Gene Name	MASP2
DTT Type	Clinical trial target	[1]
BioChemical Class	Peptidase
UniProt ID	MASP2_HUMAN
TTD ID	T07448
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.4.21.104
Sequence	MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC GEAGQYGVYTKVINYIPWIENIISDF
Function	Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. {ECO:0000269\|PubMed:10946292}.
KEGG Pathway	Complement and coagulation cascades (hsa04610 ) Staphylococcus aureus infection (hsa05150 ) Coronavirus disease - COVID-19 (hsa05171 )
Reactome Pathway	Initial triggering of complement (R-HSA-166663 ) Ficolins bind to repetitive carbohydrate structures on the target cell surface (R-HSA-2855086 ) SARS-CoV-2 activates/modulates innate and adaptive immune responses (R-HSA-9705671 ) Lectin pathway of complement activation (R-HSA-166662 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Narsoplimab	DM5KD99	IgA nephropathy	MF8Y	Phase 3	[2]
OMS721	DMK6QBZ	Atypical hemolytic uremic syndrome	3A10.Y	Phase 3	[1]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Narsoplimab, a Mannan-Binding Lectin-Associated Serine Protease-2 Inhibitor, for the Treatment of Adult Hematopoietic Stem-Cell Transplantation-Associated Thrombotic Microangiopathy. J Clin Oncol. 2022 Aug 1;40(22):2447-2457.