| DTT Name |
HUMAN cyclophilin A (CYPA)
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| Synonyms |
PPIA; Cyclophilin A; CyPA |
| Gene Name |
PPIA
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| BioChemical Class |
Cis-trans-isomerases
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 5.2.1.8
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| Sequence |
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
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| Function |
Ppiases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| KEGG Pathway |
- Viral life cycle - HIV-1 (hsa03250 )
- Necroptosis (hsa04217 )
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| Reactome Pathway |
- Uncoating of the HIV Virion (R-HSA-162585 )
- Budding and maturation of HIV virion (R-HSA-162588 )
- Integration of provirus (R-HSA-162592 )
- Early Phase of HIV Life Cycle (R-HSA-162594 )
- Minus-strand DNA synthesis (R-HSA-164516 )
- Plus-strand DNA synthesis (R-HSA-164525 )
- Binding and entry of HIV virion (R-HSA-173107 )
- Assembly Of The HIV Virion (R-HSA-175474 )
- APOBEC3G mediated resistance to HIV-1 infection (R-HSA-180689 )
- Calcineurin activates NFAT (R-HSA-2025928 )
- Basigin interactions (R-HSA-210991 )
- Neutrophil degranulation (R-HSA-6798695 )
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (R-HSA-8950505 )
- Platelet degranulation (R-HSA-114608 )
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