Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSEOPJ)

DTT Name	Bacterial Pantothenate kinase (Bact coaA)
Synonyms	Rts protein; Pantothenic acid kinase; Pantothenate kinase
Gene Name	Bact coaA
DTT Type	Literature-reported target	[1]
BioChemical Class	Kinase
UniProt ID	COAA_ECOLI
TTD ID	T91895
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.7.1.33
Sequence	MSIKEQTLMTPYLQFDRNQWAALRDSVPMTLSEDEIARLKGINEDLSLEEVAEIYLPLSR LLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRR VELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIY DVIPDGDKTVVQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQTWY INRFLKFREGAFTDPDSYFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTRERASLI LTKSANHAVEEVRLRK
Function	Phosphorylates pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP). It is the rate-limiting step in the biosynthesis of CoA.
KEGG Pathway	Pantothenate and CoA biosynthesis (ecj00770 ) Metabolic pathways (ecj01100 ) Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway	MetaCyc:PANTOTHENATE-KIN-MON EcoCyc:PANTOTHENATE-KIN-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[1]
Coenzyme A	DM1I8LU	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------

References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.