Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSRXJW)

• DTT Name: G-alpha-11 messenger RNA (GNA11 mRNA)
• Synonyms: Guanine nucleotide-binding protein subunit alpha-11 (mRNA); Guanine nucleotide-binding protein G(y) subunit alpha (mRNA); GA11 (mRNA); G-protein subunit alpha-11 (mRNA); G alpha-11 (mRNA)
• Gene Name: GNA11
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: GNA11_HUMAN
• TTD ID: T79799
• Sequence:
  MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
  IIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEK
  VTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVL
  RVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
  ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQR
  DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
• Function: Acts as an activator of phospholipase C. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
• KEGG Pathway:
  Calcium signaling pathway (hsa04020)
  cGMP-PKG signaling pathway (hsa04022)
  Vascular smooth muscle contraction (hsa04270)
  Gap junction (hsa04540)
  Cholinergic synapse (hsa04725)
  Long-term depression (hsa04730)
  Insulin secretion (hsa04911)
  GnRH signaling pathway (hsa04912)
  Chagas disease (American trypanosomiasis) (hsa05142)
  Amoebiasis (hsa05146)
  Pathways in cancer (hsa05200)
• Reactome Pathway:
  G alpha (q) signalling events (R-HSA-416476)
  ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)
  Thromboxane signalling through TP receptor (R-HSA-428930)
  Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (R-HSA-434316)
  Thrombin signalling through proteinase activated receptors (PARs) (R-HSA-456926)
  Acetylcholine regulates insulin secretion (R-HSA-399997)

Molecular Interaction Atlas (MIA) of This DTT

8 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 20577	DM76H35	Discovery agent	N.A.	Investigative	[1]
ISIS 20579	DM6X9RQ	Discovery agent	N.A.	Investigative	[1]
ISIS 20585	DMJRNWK	Discovery agent	N.A.	Investigative	[1]
ISIS 20586	DMHVQ0S	Discovery agent	N.A.	Investigative	[1]
ISIS 20990	DMLWO70	Discovery agent	N.A.	Investigative	[1]
ISIS 20993	DMFYDE4	Discovery agent	N.A.	Investigative	[1]
ISIS 20994	DM85EV7	Discovery agent	N.A.	Investigative	[1]
ISIS 20995	DMCXVPG	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 5,951,455, Antisense modulation of G-alpha-11 expression.