Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTT48SQ)

• DTT Name: Voltage-dependent anion-selective channel 3 (VDAC3)
• Synonyms: hVDAC3; VDAC3; VDAC-3; Outer mitochondrial membrane protein porin 3
• Gene Name: VDAC3
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Eukaryotic mitochondrial porin
• UniProt ID: VDAC3_HUMAN
• TTD ID: T64774
• Sequence:
  MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLET
  KYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKR
  DCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQL
  HTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNA
  SLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA
• Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
• KEGG Pathway:
  Calcium signaling pathway (hsa04020)
  cGMP-PKG signaling pathway (hsa04022)
  Parkinson's disease (hsa05012)
  Huntington's disease (hsa05016)
  Hepatitis B (hsa05161)
  HTLV-I infection (hsa05166)
  Viral carcinogenesis (hsa05203)
• Reactome Pathway:
  Mitochondrial calcium ion transport (R-HSA-8949215)
  Ub-specific processing proteases (R-HSA-5689880)

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PRLX93936	DM8J5H1	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

References

• [1] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.