Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTPDRC)

DTT Name Pseudomonas Psl exopolysaccharide (Pseudo pslG)
Synonyms PslG
Gene Name Pseudo pslG
DTT Type
Clinical trial target
 [1]
UniProt ID
Q9I1N2_PSEAE
TTD ID
T42882
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARKGLYLGGSALLLAVVLLLVFWGRPADAEIQVLKAPRAVVWKDFLGVNAQFLWFSPER
YNKQIDRLQDLGLEWVRLDLHWDRLETAEDQYQLASLDQLVKDLEARQLKSVFYLVGSAR
FITTAPFYSPFQDQYPPRDPEVFARRMAMLSQRYPSVAAWQVWNEPNLIGFWRPKADPEG
YAKLLQASTIALRMVDPEKPVVSAGMAFFSEMPDGRTMFDALGHLGVESLGTIATYHPYT
QLPEGNYPWNLDFVSHANQINRALRNAGVPAIWSTEWGWSAYKGPKELQDIIGVEGQADY
VLRRLALMSALDYDRIFLFTLSDLDQRASVRDRDYGLLDLDANPKPVYLALQRFLKVTGP
KLRPADPPVTEDLPDGSFSIGWTREDGRNVWLFWSARGGNVRLPKLKEATLHDPLSGKVT
PLSGSDGLEVPVKSSLQMLVWE
Function A extracellular matrix component of P. aeruginosa biofilms. A galactose-rich and mannose-rich exopolysaccharide.
KEGG Pathway
Biofilm formation - Pseudomonas aeruginosa (pae02025 )
BioCyc Pathway
PAER208964:G1FZ6-2277-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
MEDI3902 DMOXKIC Ventilator-associated pneumonia PK81.0 Phase 2 [1]
------------------------------------------------------------------------------------

References

1 A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014 Nov 12;6(262):262ra155.