Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTSCQ2)

DTT Name	Ornithine delta-aminotransferase (OAT)
Synonyms	Ornithine--oxo-acid aminotransferase; Ornithine aminotransferase, mitochondrial
Gene Name	OAT
DTT Type	Literature-reported target	[1]
BioChemical Class	Transaminase
UniProt ID	OAT_HUMAN
TTD ID	T62073
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.6.1.13
Sequence	MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI KEDELRESIEIINKTILSF
Function	Catalyzes the transfer of the delta-amino group from L-ornithine.
KEGG Pathway	Arginine and proline metabolism (hsa00330 ) Metabolic pathways (hsa01100 ) Biosynthesis of antibiotics (hsa01130 )
Reactome Pathway	Amino acid synthesis and interconversion (transamination) (R-HSA-70614 )
BioCyc Pathway	MetaCyc:HS00832-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Canaline	DMNLTGF	Discovery agent	N.A.	Investigative	[1]
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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.