Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTSUI2)

DTT Name	Aspergillus Dihydroorotate dehydrogenase (Aspergillus DHODH)
Synonyms	Dihydroorotate oxidase
Gene Name	Aspergillus DHODH
DTT Type	Clinical trial target	[1]
UniProt ID	G5EB61_EMENI
TTD ID	T95410
EC Number	EC 1.3.5.2
Sequence	MATNSFRKLTFSGASRLGGCRRLPLTCRQLRFASDSGAAAATTKATAESAAESASINVKE APKKAGRGLRRTVLGTSLALTLLVGYVYGTDTRASVHRYGVVPLIRALYPDAEDAHHIGV DTLKMLYKYGLHPRERGDPDGDGALATEVFGYTLSNPIGISGGLDKHAEIPDPLFAIGPA IVEVGGTTPLPQDGNPRPRVFRLPSQRAMINRYGLNSKGADHMAAILEQRVRDFAYANGF GAYDAAKQRVLDGEAGVPPGSLQPGKLLAVQVAKNKATPDGDIEAIKRDYVYCVDRVAKY ADILVVNVSSPNTPGLRDLQATAPLTAILSAVVGAAKSVNRKTKPYVMVKVSPDEDSDEQ VSGICDAVRASGVDGVIVGNTTNRRPDPIPQGYTLPAKEQATLKETGGYSGPQLFDRTVA LVARYRSMLDAESETAGSAKDSAATIAQTEPGSENVPPVEAPSGLPRKVIFASGGITNGK QAHAVLDTGASVAMMYTGVVYGGVGTVTRVKQELRTAKKE
KEGG Pathway	Pyrimidine metabolism (ani00240 ) Metabolic pathways (ani01100 ) Biosynthesis of cofactors (ani01240 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
F901318	DM2CUS0	Fungal infection	1F29-1F2F	Phase 2	[1]
------------------------------------------------------------------------------------

References

1	Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00231-18.