Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TTTYNAM)
| DTT Name | Endophilin-A2 (SH3GL1) | ||||
|---|---|---|---|---|---|
| Synonyms | SH3D2B; SH3 domain-containing GRB2-like protein 1; SH3 domain protein 2B; Extra eleven-nineteen leukemia fusion gene protein; Endophilin-2; EEN fusion partner of MLL; EEN; CNSA1 | ||||
| Gene Name | SH3GL1 | ||||
| DTT Type |
Literature-reported target
|
[1] | |||
| BioChemical Class |
Endophilin family
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| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| Sequence |
MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV EVLVPLPQ |
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| Function | Implicated in endocytosis. May recruit other proteins to membranes with high curvature. | ||||
| KEGG Pathway | |||||
| Reactome Pathway | |||||