Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTUF10B)

DTT Name Eukaryotic initiation factor 4E (EIF4E)
Synonyms eIF4F 25 kDa subunit; eIF4E; eIF-4F 25 kDa subunit; eIF-4E; Eukaryotic translation initiation factor 4E; EIF4F; EIF4EL1
Gene Name EIF4E
DTT Type
Literature-reported target
 [1]
UniProt ID
IF4E_HUMAN
TTD ID
T31186
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Function
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
KEGG Pathway
EGFR tyrosine kinase inhibitor resistance (hsa01521 )
HIF-1 signaling pathway (hsa04066 )
mTOR signaling pathway (hsa04150 )
PI3K-Akt signaling pathway (hsa04151 )
Longevity regulating pathway (hsa04211 )
Insulin signaling pathway (hsa04910 )
Reactome Pathway
L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827 )
Transport of the SLBP independent Mature mRNA (R-HSA-159227 )
Transport of the SLBP Dependant Mature mRNA (R-HSA-159230 )
Transport of Mature mRNA Derived from an Intronless Transcript (R-HSA-159231 )
mTORC1-mediated signalling (R-HSA-166208 )
Deadenylation of mRNA (R-HSA-429947 )
Translation initiation complex formation (R-HSA-72649 )
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662 )
Ribosomal scanning and start codon recognition (R-HSA-72702 )
GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706 )
ISG15 antiviral mechanism (R-HSA-1169408 )

References

1 Signalling to eIF4E in cancer. Biochem Soc Trans. 2015 Oct;43(5):763-72.