Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTUJ0G5)

DTT Name	HUMAN catechol-O-methyl-transferase (COMT)
Synonyms	S-COMT; MB-COMT; Catechol-O-methyltransferase; COMT
Gene Name	COMT
BioChemical Class	Methyltransferase
UniProt ID	COMT_HUMAN
TTD ID	T00442
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.1.1.6
Sequence	MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Function	Human protein catechol-O-methyltransferase interacts with SARS-CoV-2 Nsp7 protein with high significance, which indicates COMT as a potential therapeutic target.
KEGG Pathway	Steroid hormone biosynthesis (hsa00140 ) Tyrosine metabolism (hsa00350 ) Metabolic pathways (hsa01100 ) Dopaminergic synapse (hsa04728 )
Reactome Pathway	Enzymatic degradation of dopamine by COMT (R-HSA-379397 ) Enzymatic degradation of Dopamine by monoamine oxidase (R-HSA-379398 ) Potential therapeutics for SARS (R-HSA-9679191 ) Methylation (R-HSA-156581 )
BioCyc Pathway	MetaCyc:HS01791-MON

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Catechol O-methyltransferase (COMT) DME Info

Gene Name

COMT

3 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[2]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[3]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[4]
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1 Investigative Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
METHYLENEDIOXYMETHAMPHETAMINE	DMYVU47	Discovery agent	N.A.	Investigative	[5]
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References

1	A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.
2	Catechol-O-methyltransferase: substrate-specificity and stereoselectivity for beta-adrenoceptor agents. Xenobiotica. 1986 Jan;16(1):47-52.
3	Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):651-60.
4	Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J Pharmacol Exp Ther. 1994 Mar;268(3):1242-51.
5	Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44.