Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTV8DM2)

DTT Name	Bacterial Dihydrofolate reductase (Bact DHFR)
Synonyms	Bact Dihydrofolate reductase
Gene Name	Bact DHFR
DTT Type	Clinical trial target	[1]
UniProt ID	DYR_ECOLI
TTD ID	T02702
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 1.5.1.3
Sequence	MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
KEGG Pathway	One carbon pool by folate (ecj00670 ) Folate biosynthesis (ecj00790 ) Metabolic pathways (ecj01100 ) Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway	MetaCyc:DIHYDROFOLATEREDUCT-MON EcoCyc:DIHYDROFOLATEREDUCT-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Iclaprim	DM7YNV9	Bacterial infection	1A00-1C4Z	Phase 3	[1]
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3 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AR-709	DMUI81C	Bacterial infection	1A00-1C4Z	Terminated	[2]
DIAVERIDINE	DMB74CM	Bacterial infection	1A00-1C4Z	Terminated	[3]
Epiroprim	DM6IY4M	Bacterial infection	1A00-1C4Z	Terminated	[4]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Dihydrofolate reductase (folA) DME Info

Gene Name

folA

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[5], [6]
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References

1	Iclaprim: a novel dihydrofolate reductase inhibitor for skin and soft tissue infections.Future Microbiol.2009 Mar;4(2):131-44.
2	Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America
3	Acute and sub-chronic toxicity study of diaveridine in Wistar rats.Regul Toxicol Pharmacol.2015 Oct;73(1):232-40.
4	In vitro activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with brodimoprim and dapsone, against Mycobacterium ... Int J Antimicrob Agents. 1999 Aug;12(4):319-23.
5	Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
6	The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.