Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTV9MQG)

• DTT Name: Gamma-aminobutyric acid uptake (GABAU)
• Synonyms: GABA uptake
• Gene Name: GABAU
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T30374

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tiagabine	DMKSQG0	Epilepsy	8A60-8A68	Approved	[1]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC 05-2045	DMPZ1EC	N. A.	N. A.	Terminated	[2]

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(R)-nipecotic acid	DMWGB40	Discovery agent	N.A.	Investigative	[3]
4-substituted 2,4-dioxobutanoic acids	DMELGKY	Discovery agent	N.A.	Investigative	[3]
Cis-4-hydroxynipecotic acid	DMX07BG	Discovery agent	N.A.	Investigative	[4]
NNC 711	DM0C8N3	Discovery agent	N.A.	Investigative	[5]
THPO	DMJD479	Discovery agent	N.A.	Investigative	[6]

References

• [1] Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
• [2] GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000 Sep;39(12):2399-407.
• [3] GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr Pharm Des. 2000 Aug;6(12):1193-209.
• [4] GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid. Drug Des Deliv. 1987 Sep;2(1):9-21.
• [5] Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):334-41.
• [6] Anticonvulsant activity of intracerebroventricularly administered glial GABA uptake inhibitors and other GABAmimetics in chemical seizure models. Epilepsy Res. 1989 Jul-Aug;4(1):34-41.