Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVNA43)

• DTT Name: Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA)
• Synonyms: kdsA; Phospho-2-dehydro-3-deoxyoctonate aldolase; KDOPS; KDOP synthase; KDO8PS; KDO8P synthase; KDO8-P synthase; KDO-8-phosphate synthetase; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; 3-Deoxy-d-manno-2-octulosonate-8-phosphate synthase; 2-dehydro-3-deoxyphosphooctonate aldolase
• Gene Name: Bact kdsA
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Alkyl aryl transferase
• UniProt ID: KDSA_ECOLI
• TTD ID: T23688
• Sequence:
  MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDK
  ANRSSIHSYRGPGLEEGMKIFQELKQTFGVKIITDVHEPSQAQPVADVVDVIQLPAFLAR
  QTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFKEGGNEKVILCDRGANFGYDNLVVD
  MLGFSIMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEA
  HPDPEHAKCDGPSALPLAKLEPFLKQMKAIDDLVKGFEELDTSK
• Function: Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.
• KEGG Pathway:
  Lipopolysaccharide biosynthesis (ecj00540)
  Metabolic pathways (ecj01100)
  Biosynthesis of nucleotide sugars (ecj01250)
• BioCyc Pathway:
  MetaCyc:KDO-8PSYNTH-MON
  EcoCyc:KDO-8PSYNTH-MON

Molecular Interaction Atlas (MIA) of This DTT

8 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-Deoxy-Ribofuranose-5'-Phosphate	DMH9WFD	Discovery agent	N.A.	Investigative	[1]
2-(Phosphonooxy)Butanoic Acid	DM4V2ZO	Discovery agent	N.A.	Investigative	[2]
2-Phosphoglyceric Acid	DMX6GH5	Discovery agent	N.A.	Investigative	[1]
3-Fluoro-2-(Phosphonooxy)Propanoic Acid	DMTY92S	Discovery agent	N.A.	Investigative	[1]
Arabinose-5-Phosphate	DMAM619	Discovery agent	N.A.	Investigative	[1]
Erythose-4-Phosphate	DMLT7FQ	Discovery agent	N.A.	Investigative	[1]
Phosphoenolpyruvate	DM2D947	Discovery agent	N.A.	Investigative	[1]
Ribose-5-Phosphate	DMRKO49	Discovery agent	N.A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.