Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVSEBF)

DTT Name	Proteinase activated receptor 3 (F2RL2)
Synonyms	Thrombin receptor-like 2; Protease activated receptor 3; PAR-3; F2RL2; Coagulation factor II receptor-like 2
Gene Name	F2RL2
DTT Type	Literature-reported target	[1]
BioChemical Class	GPCR rhodopsin
UniProt ID	PAR3_HUMAN
TTD ID	T24542
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWT GATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLF FRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCS ILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQP DITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYV KASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFL MSKTRNHSTAYLTK
Function	Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
KEGG Pathway	Neuroactive ligand-receptor interaction (hsa04080 ) Complement and coagulation cascades (hsa04610 )
Reactome Pathway	G alpha (q) signalling events (R-HSA-416476 ) Thrombin signalling through proteinase activated receptors (PARs) (R-HSA-456926 ) Peptide ligand-binding receptors (R-HSA-375276 )

References

1	Protease-activated receptors: the role of cell-surface proteolysis in signalling. Essays Biochem. 2002;38:169-83.