Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVYIH7)

DTT Name	Schistosoma Purine nucleoside phosphorylase (sch PNP)
Synonyms	sch Purine nucleoside phosphorylase; sch Inosine-guanosine phosphorylase
Gene Name	sch PNP
DTT Type	Clinical trial target	[1]
UniProt ID	Q9BMI9_SCHMA
TTD ID	T54519
EC Number	EC 2.4.2.1
Sequence	MHESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYTKIPNFPQ TSVVGHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVKILMVSNAAG GLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRFPALSNAYDRDLRKLAVQVA EENGFGNLVHQGVYVMNGGPCYETPAECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAV SLVTNISVLDVESDLKPNHEEVLATGAQRAELMQSWFEKIIEKLPKD
Function	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FP-253-GDEPT	DM8BG0M	Prostate cancer	2C82.0	Phase 1	[1]
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References

1	Purine nucleoside phosphorylase and fludarabine phosphate gene-directed enzyme prodrug therapy suppresses primary tumour growth and pseudo-metastases in a mouse model of prostate cancer. J Gene Med. 2004 Dec;6(12):1343-57.