Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTW76JE)

DTT Name	LDHA messenger RNA (LDHA mRNA)
Synonyms	LDH-A; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59
Gene Name	LDHA
DTT Type	Clinical trial target	[1]
UniProt ID	LDHA_HUMAN
TTD ID	T32790
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 1.1.1.27
Sequence	MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
KEGG Pathway	Glycolysis / Gluconeogenesis (hsa00010 ) Cysteine and methionine metabolism (hsa00270 ) Pyruvate metabolism (hsa00620 ) Propanoate metabolism (hsa00640 ) Metabolic pathways (hsa01100 ) HIF-1 signaling pathway (hsa04066 ) Glucagon signaling pathway (hsa04922 ) Central carbon metabolism in cancer (hsa05230 )
Reactome Pathway	Pyruvate metabolism (R-HSA-70268 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nedosiran	DMCHWX1	Primary hyperoxaluria type 1	5C51.20	Approved	[1]
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References

1	Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria. Kidney Int Rep. 2021 Feb 3;6(4):1088-1098.