Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWAQBO)

• DTT Name: Lysine-specific demethylase 4E (KDM4E)
• Synonyms: Lysine-specific demethylase 4D-like; KDM4DL; KDM4D-like protein
• Gene Name: KDM4E
• DTT Type: Patented-recorded target; [1]
• BioChemical Class: Paired donor oxygen oxidoreductase
• UniProt ID: KDM4E_HUMAN
• TTD ID: T17036
• EC Number: EC 1.14.11.-
• Sequence:
  MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
  DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
  RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
  MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
  HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
  GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
  DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
  LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
  MGTRSRAQGHRPQLPLANDLMTNLSL
• Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
• BioCyc Pathway: MetaCyc:MON66-43206

Molecular Interaction Atlas (MIA) of This DTT

19 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxyqunoline analog 1	DMAJFDT	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 2	DMX3TZ7	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 3	DMCMKIL	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 4	DMGQMCZ	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 5	DM5QAKR	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 1	DM2P509	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 2	DMWSZMC	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 3	DM7XS9G	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 4	DMUE7R5	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 5	DM673GR	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 6	DM106SU	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 7	DM13K8R	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 8	DMNV0OA	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 9	DMTMYJ6	N. A.	N. A.	Patented	[1]
PMID25468267-Compound-46	DMSKCEH	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 1	DMJNE4V	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 2	DMCNWPI	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 3	DM4XAGS	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 4	DMGPCSR	N. A.	N. A.	Patented	[1]

References

• [1] KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44.