Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWF7UG)

DTT Name	Somatostatin (SST)
Synonyms	Somatostatin-28; Somatostatin-14; SST; Growth hormone release-inhibiting factor
Gene Name	SST
DTT Type	Successful target	[1]
BioChemical Class	Somatostatin cortistatin
UniProt ID	SMS_HUMAN
TTD ID	T95479
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEP NQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
Function	Somatostatin inhibits the release of somatotropin.
KEGG Pathway	Gastric acid secretion (hsa04971 )
Reactome Pathway	G alpha (i) signalling events (R-HSA-418594 ) Peptide ligand-binding receptors (R-HSA-375276 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[1]
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References

1	Somatostatin, Alzheimer's disease and cognition: an old story coming of age Prog Neurobiol. 2009 Oct;89(2):153-61.