Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TTWOCZI)
| DTT Name | Cation channel sperm-associated protein (CatSper) | ||||
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| Synonyms | Chemokine (C-C motif) receptor | ||||
| Gene Name | CatSper | ||||
| DTT Type |
Literature-reported target
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[1] | |||
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| TTD ID | |||||
| Function |
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
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Molecular Interaction Atlas (MIA) of This DTT
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2 Investigative Drug(s) Targeting This DTT
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