Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXI3KF)

DTT Name	Pyridoxal kinase (PDXK)
Synonyms	Pyridoxine kinase; PDXK
Gene Name	PDXK
DTT Type	Literature-reported target	[1]
BioChemical Class	Kinase
UniProt ID	PDXK_HUMAN
TTD ID	T76522
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.7.1.35
Sequence	MEEECRVLSIQSHVIRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSD ELQELYEGLRLNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVCDPVLGDKW DGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGP DTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAM LLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRMVQSKRDI EDPEIVVQATVL
Function	Required for synthesisof pyridoxal-5-phosphate from vitamin B6.
KEGG Pathway	Vitamin B6 metabolism (hsa00750 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Vitamins B6 activation to pyridoxal phosphate (R-HSA-964975 ) Neutrophil degranulation (R-HSA-6798695 )
BioCyc Pathway	MetaCyc:HS08466-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-betagamma-meATP	DMTNQCE	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.