Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXZ7W0)

DTT Name	Rheumatoid arthritis-related antigen RA-A47 (SERPINH1)
Synonyms	Serpin H1; SERPINH2; PIG14; HSP47; Colligin; Collagen-binding protein; Cell proliferation-inducing gene 14 protein; CBP2; CBP1; AsTP3; Arsenic-transactivated protein 3; 47 kDa heat shock protein
Gene Name	SERPINH1
DTT Type	Literature-reported target	[1]
UniProt ID	SERPH_HUMAN
TTD ID	T56104
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAK DQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSN STARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQT TDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRT GLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKK AVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELD TDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL
Function	Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
Reactome Pathway	Collagen biosynthesis and modifying enzymes (R-HSA-1650814 )

References

1	Heat shock protein 47 can be a new target molecule for intestinal fibrosis related to inflammatory bowel disease. Inflamm Bowel Dis. 2010 Dec;16(12):2004-6.