Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTY0DN9)

DTT Name	Serum amyloid A-1 protein (SAA1)
Synonyms	SAA
Gene Name	SAA1
DTT Type	Literature-reported target	[1]
UniProt ID	SAA1_HUMAN
TTD ID	T55447
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNY DAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPE KY
Function	Major acute phase protein.
Reactome Pathway	G alpha (q) signalling events (R-HSA-416476 ) G alpha (i) signalling events (R-HSA-418594 ) Formyl peptide receptors bind formyl peptides and many other ligands (R-HSA-444473 ) TAK1-dependent IKK and NF-kappa-B activation (R-HSA-445989 ) Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807 ) Advanced glycosylation endproduct receptor signaling (R-HSA-879415 ) TRAF6 mediated NF-kB activation (R-HSA-933542 ) Amyloid fiber formation (R-HSA-977225 ) Scavenging by Class B Receptors (R-HSA-3000471 )

References

1	Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis. J Clin Microbiol. 2017 Oct;55(10):3057-3071.