Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTY0OJN)

DTT Name Heat shock protein beta-8 (HSPB8)
Synonyms
Small stress proteinlike protein HSP22; Small stress protein-like protein HSP22; Protein kinase H11; PP1629; HspB8; Heat shock protein beta8; HSP22; E2induced gene 1 protein; E2IG1; E2-induced gene 1 protein; CRYAC; Alphacrystallin C chain; Alpha-crystallin C chain
Gene Name HSPB8
DTT Type
Literature-reported target
 [1]
BioChemical Class
Heat shock protein
UniProt ID
HSPB8_HUMAN
TTD ID
T35161
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAW
PGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVE
VSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGES
SFNNELPQDSQEVTCT
Function Displays temperature-dependent chaperone activity.
Reactome Pathway
HSF1-dependent transactivation (R-HSA-3371571 )

References

1 HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons. Int J Med Sci. 2017 Oct 15;14(13):1335-1341.