Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTY3BRA)

• DTT Name: ZNF217 messenger RNA (ZNF217 mRNA)
• Synonyms: Zinc finger protein 217 (mRNA); ZABC1 (mRNA)
• Gene Name: ZNF217
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: ZN217_HUMAN
• TTD ID: T70278
• Sequence:
  MQSKVTGNMPTQSLLMYMDGPEVIGSSLGSPMEMEDALSMKGTAVVPFRATQEKNVIQIE
  GYMPLDCMFCSQTFTHSEDLNKHVLMQHRPTLCEPAVLRVEAEYLSPLDKSQVRTEPPKE
  KNCKENEFSCEVCGQTFRVAFDVEIHMRTHKDSFTYGCNMCGRRFKEPWFLKNHMRTHNG
  KSGARSKLQQGLESSPATINEVVQVHAAESISSPYKICMVCGFLFPNKESLIEHRKVHTK
  KTAFGTSSAQTDSPQGGMPSSREDFLQLFNLRPKSHPETGKKPVRCIPQLDPFTTFQAWQ
  LATKGKVAICQEVKESGQEGSTDNDDSSSEKELGETNKGSCAGLSQEKEKCKHSHGEAPS
  VDADPKLPSSKEKPTHCSECGKAFRTYHQLVLHSRVHKKDRRAGAESPTMSVDGRQPGTC
  SPDLAAPLDENGAVDRGEGGSEDGSEDGLPEGIHLDKNDDGGKIKHLTSSRECSYCGKFF
  RSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHHKEKQTDVAAEVKNDGKNQ
  DTEDALLTADSAQTKNLKRFFDGAKDVTGSPPAKQLKEMPSVFQNVLGSAVLSPAHKDTQ
  DFHKNAADDSADKVNKNPTPAYLDLLKKRSAVETQANNLICRTKADVTPPPDGSTTHNLE
  VSPKEKQTETAADCRYRPSVDCHEKPLNLSVGALHNCPAISLSKSLIPSITCPFCTFKTF
  YPEVLMMHQRLEHKYNPDVHKNCRNKSLLRSRRTGCPPALLGKDVPPLSSFCKPKPKSAF
  PAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAPSNLKSHRPQQNVGVQGAATRQQQSE
  MFPKTSVSPAPDKTKRPETKLKPLPVAPSQPTLGSSNINGSIDYPAKNDSPWAPPGRDYF
  CNRSASNTAAEFGEPLPKRLKSSVVALDVDQPGANYRRGYDLPKYHMVRGITSLLPQDCV
  YPSQALPPKPRFLSSSEVDSPNVLTVQKPYGGSGPLYTCVPAGSPASSSTLEGKRPVSYQ
  HLSNSMAQKRNYENFIGNAHYRPNDKKT
• Function: Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. Binds to the promoters of target genes and functions as repressor.
• Reactome Pathway: Estrogen-dependent gene expression (R-HSA-9018519)

Molecular Interaction Atlas (MIA) of This DTT

8 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 114527	DM1OVSW	Discovery agent	N.A.	Investigative	[1]
ISIS 114530	DMSEQ61	Discovery agent	N.A.	Investigative	[1]
ISIS 114531	DMZSUA9	Discovery agent	N.A.	Investigative	[1]
ISIS 114532	DMJ7BOL	Discovery agent	N.A.	Investigative	[1]
ISIS 114537	DMD9O2H	Discovery agent	N.A.	Investigative	[1]
ISIS 114559	DMMOPUK	Discovery agent	N.A.	Investigative	[1]
ISIS 114563	DMD2J3Q	Discovery agent	N.A.	Investigative	[1]
ISIS 14548	DMHWGL0	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 6,242,590, Antisense modulation of zinc finger protein-217 expression.