Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTY5F9C)

DTT Name	Major prion protein (PRNP)
Synonyms	Prion protein PrP(C); Prion protein; PrP33-35C; PrP27-30; PrP; PRNP; CD230 antigen; ASCR
Gene Name	PRNP
DTT Type	Literature-reported target	[1]
UniProt ID	PRIO_HUMAN
TTD ID	T08722
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV ILLISFLIFLIVG
Function	The physiological function of prp is not known.
KEGG Pathway	Ferroptosis (hsa04216 ) Prion disease (hsa05020 ) Pathways of neurodegeneration - multiple diseases (hsa05022 )
Reactome Pathway	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523 ) NCAM1 interactions (R-HSA-419037 )

References

1	Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency. PLoS Pathog. 2017 Aug 11;13(8):e1006553.