Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTY8KJS)

DTT Name Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut)
Synonyms Deoxyuridine triphosphate nucleotidohydrolase; Deoxyuridine 5'-triphosphate nucleotidohydrolase; DUTPase; DUTP pyrophosphatase of Escherichia coli; Bact dut
Gene Name Bact dut
DTT Type
Literature-reported target
 [1]
BioChemical Class
Acid anhydrides hydrolase
UniProt ID
DUT_ECOLI
TTD ID
T24334
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMKKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLNDAVELAPGDTTLVPTGLAIHIA
DPSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQM
IFVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ
Function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
KEGG Pathway
Pyrimidine metabolism (ecj00240 )
Metabolic pathways (ecj01100 )
Nucleotide metabolism (ecj01232 )
BioCyc Pathway
MetaCyc:DUTP-PYROP-MON
EcoCyc:DUTP-PYROP-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
10 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
1-(3-tritylaminopropyl)uracil DMZPJM4 Discovery agent N.A. Investigative [2]
1-[(Z)-4-trityloxy-2-butenyl]uracil DMIHBFO Discovery agent N.A. Investigative [2]
1-[2-(trityloxy)ethoxymethyl]uracil DM98F0U Discovery agent N.A. Investigative [2]
1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil DMHXAMR Discovery agent N.A. Investigative [2]
2'-deoxyuridine 5'-alpha,beta-imido-diphosphate DMXV27U Discovery agent N.A. Investigative [3]
2'-Deoxyuridine 5'-Alpha,Beta-Imido-Triphosphate DMOHABR Discovery agent N.A. Investigative [1]
2'-deoxyuridylic acid DMPV1LU Discovery agent N.A. Investigative [1]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [1]
Deoxyuridine-5'-Diphosphate DMIFMDC Discovery agent N.A. Investigative [3]
Deoxyuridine-5'-Triphosphate DMCG5V2 Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 10 Investigative Drug(s)

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem. 2006 Jul 13;49(14):4183-95.
3 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.