Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTYGQ8A)

DTT Name Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)
Synonyms Minibrain-related kinase; MIRK; Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Gene Name DYRK1B
DTT Type
Patented-recorded target
 [1]
BioChemical Class
Kinase
UniProt ID
DYR1B_HUMAN
TTD ID
T82720
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.7.12.1
Sequence
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
Function
Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities.
BioCyc Pathway
MetaCyc:HS02690-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
18 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID28766366-Compound-Scheme14BINDY DMBQ0RN N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme21Left DMWTRUK N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme21Right DMF3X40 N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme25-2 DM7OGWH N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme25-3 DMGVT5Y N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme25-4 DMOD9BY N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme2WO2012/098065bottom DMO4Q95 N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme2WO2012/098065upper DMVJDRI N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme4Bottom DMDXIU9 N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme4Upper DMPH4JV N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme5 DMO6KZ5 N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme7WO2012/098070bottom DMQV6R0 N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme7WO2012/098070upper DMGAQR5 N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme9EHT1610 DMMZGC8 N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme9EHT3356 DMVBPML N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme9EHT5372 DM0O18N N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme9EHT6840 DMVY6PX N. A. N. A. Patented [1]
PMID28766366-Compound-Scheme9EHT9851 DM7RPKM N. A. N. A. Patented [1]
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⏷ Show the Full List of 18 Patented Agent(s)
3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID23642479C17 DM4JWMA Discovery agent N.A. Investigative [2]
PMID24900699C68 DM2V4MJ Discovery agent N.A. Investigative [3]
WO2013026806C72 DM21WOP Discovery agent N.A. Investigative [4]
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References

1 Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199.
2 Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61.
3 Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease. ACS Med Chem Lett. 2013 Apr 26;4(6):502-3.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2010).