Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTYQ4AE)

DTT Name Plasmodium Adenylosuccinate synthetase (Malaria Adss)
Synonyms IMP--aspartate ligase; Adenylosuccinate synthase; AdSS; AMPSase
Gene Name Malaria Adss
DTT Type
Clinical trial target
 [1]
BioChemical Class
Carbon-nitrogen ligase
UniProt ID
PURA_PLAFA
TTD ID
T89054
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 6.3.4.4
Sequence
MNIFDHQIKNVDKGNVVAILGAQWGDEGKGKIIDMLSEYSDITCRFNGGANAGHTISVND
KKYALHLLPCGVLYDNNISVLGNGMVIHVKSLMEEIESVGGKLLDRLYLSNKAHILFDIH
QIIDSIQETKKLKEGKQIGTTKRGIGPCYSTKASRIGIRLGTLKNFENFKNMYSKLIDHL
MDLYNITEYDKEKELNLFYNYHIKLRDRIVDVISFMNTNLENNKKVLIEGANAAMLDIDF
GTYPYVTSSCTTVGGVFSGLGIHHKKLNLVVGVVKSYLTRVGCGPFLTELNNDVGQYLRE
KGHEYGTTTKRPRRCGWLDIPMLLYVKCINSIDMINLTKLDVLSGLEEILLCVNFKNKKT
GELLEKGCYPVEEEISEEYEPVYEKFSGWKEDISTCNEFDELPENAKKYILAIEKYLKTP
IVWIGVGPNRKNMIVKKNFNLN
Function Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
10 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(C8-R)-Hydantocidin 5'-Phosphate DM5WH6R Discovery agent N.A. Investigative [2]
(C8-S)-Hydantocidin 5'-Phosphate DMMH179 Discovery agent N.A. Investigative [2]
(Carboxyhydroxyamino)Ethanoic Acid DMZB0C3 Discovery agent N.A. Investigative [2]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [2]
6-Cl-IMP DMNTDFV Discovery agent N.A. Investigative [3]
6-O-Phosphoryl Inosine Monophosphate DM6YHBR Discovery agent N.A. Investigative [2]
Diphosphate DMHY30B Discovery agent N.A. Investigative [2]
Guanosine-5'-Diphosphate DM0MUKQ Discovery agent N.A. Investigative [2]
Hydantocidin-5'-Monophosphate DMOTXP1 Discovery agent N.A. Investigative [2]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [2]
------------------------------------------------------------------------------------
⏷ Show the Full List of 10 Investigative Drug(s)

References

1 Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Clin Cancer Res. 2006 Jun 15;12(12):3754-61.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants. Biol Reprod. 1994 Jun;50(6):1403-12.