Details of the Drug Therapeutic Target (DTT) | DrugMAP

General Information of Drug Therapeutic Target (DTT) (ID: TTZCG0Q)

DTT Name	N-acylglucosamine 2-epimerase (RENBP)
Synonyms	RnBP; Renin-binding protein; RENBP; N-acetyl-D-glucosamine 2-epimerase; GlcNAc 2-epimerase; AGE
Gene Name	RENBP
DTT Type	Literature-reported target				[1]
BioChemical Class	Racemases and epimerases
UniProt ID	RENBP_HUMAN
TTD ID	T24588
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 5.1.3.8
Sequence	MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYD DLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTR DGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQL QGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVS EGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHG GLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQF RDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPT PACRGAE
Function	Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
KEGG Pathway	Amino sugar and nucleotide sugar metabolism (hsa00520 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Synthesis of UDP-N-acetyl-glucosamine (R-HSA-446210 )

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

N-acetyl-D-glucosamine 2-epimerase (AGE) DME Info

Gene Name

RENBP

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-Acetyl-D-glucosamine	DM1XBWR	Autoimmune diabetes	5A10	Approved	[2]
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References

1	Development of bFGF-Chitosan Matrices and Their Interactions with Human Dermal Fibroblast Cells. J Biomater Sci Polym Ed. 2009;20(10):1335-51.
2	Production of N-acetyl-d-neuraminic acid by whole cells expressing Bacteroides thetaiotaomicron N-acetyl-d-glucosamine 2-epimerase and Escherichia coli N-acetyl-d-neuraminic acid aldolase. J Agric Food Chem. 2019 Jun 5;67(22):6285-6291.