Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZGCP6)

DTT Name EIF4E messenger RNA (EIF4E mRNA)
Synonyms
mRNA capbinding protein (mRNA); mRNA cap-binding protein (mRNA); eIF4F 25 kDa subunit (mRNA); eIF4E (mRNA); eIF-4F 25 kDa subunit (mRNA); eIF-4E (mRNA); Eukaryotic translation initiation factor 4E (mRNA); EIF4F (mRNA); EIF4EL1 (mRNA)
Gene Name EIF4E
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
IF4E_HUMAN
TTD ID
T48614
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Function
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
KEGG Pathway
RNA transport (hsa03013 )
HIF-1 signaling pathway (hsa04066 )
mTOR signaling pathway (hsa04150 )
PI3K-Akt signaling pathway (hsa04151 )
Insulin signaling pathway (hsa04910 )
Reactome Pathway
mTORC1-mediated signalling (R-HSA-166208 )
ISG15 antiviral mechanism (R-HSA-1169408 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
7-Methyl-Gpppa DME39U2 Discovery agent N.A. Investigative [1]
7-Methyl-Guanosine-5'-Triphosphate DMCGNUO Discovery agent N.A. Investigative [1]
7n-Methyl-8-Hydroguanosine-5'-Diphosphate DM2403T Discovery agent N.A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Prostate cancer 2C82 Prostate 8.54E-05 0.92 0.88
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.